Immunogen | PurifiedNa+/K+ATPaseisolatedfrommembranefractionsofrabbitkidneyoutermedulla. |
Clone | C464.8 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | Recognizestheβ-1subunitisoformofNa+/K+. |
Isotype | IgG2aκ |
SpeciesReactivity | - Bovine
- Canine
- Human
- Rat
- Rabbit
|
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | TheproteinencodedbythisgenebelongstothefamilyofP-typecationtransportATPases,andtothesubfamilyofNa+/K+-ATPases.Na+/K+-ATPaseisanintegralmembraneproteinresponsIBLeforestablishingandmaintainingtheelectRochemicalgrADIentsofNaandKionsacrosstheplasmamembrane.Thesegradientsareessentialforosmoregulation,forsodium-coupledtransportofavarietyoforganicandinorganicmolecules,andforelectricalexcitABIlityofnerveandmuscle.Thisenzymeiscomposedoftwosubunits,alargecatalyticsubunit(alpha)andasmallerglycoproteinsubunit(beta).ThecatalyticsubunitofNa+/K+-ATPaseisencodedbymultiplegenes.Thisgeneencodesanalpha3subunit. |
GeneSymbol | - ATP1A3
- MGC13276
- RDP
- IIIsubunit).
- DYT12
- +K
- Na
|
PurificationMethod | ProteinGPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P13637#Thisisthecatalyticcomponentoftheactiveenzyme,whichcatalyzesthehydrolysisofATPcoupledwiththeexchangeofsodiumandpotassiumionsacrosstheplasmamembrane.Thisactioncreatestheelectrochemicalgradientofsodiumandpotassiumions,providingtheenergyforactivetransportofvariousnutrients. SIZE:1013aminoacids;111749Da SUBUNIT:Composedofthreesubunits:alpha(catalytic),betaandgamma. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. DISEASE:SwissProt:P13637#DefectsinATP1A3arethecauseofdystonia-12(DYT12)[MIM:128235];alsoknownasrapid-onsetdystoniaparkinsonism(RDP).DYT12isanautosomaldominantformofdystonia-parkinsonismcharacterizedbyanunusuallyrapidevolutionofsignsandsymptoms.Affectedpersonsdevelopdystoniaandparkinsonismbetween14and45yearsofage.Thesuddenonsetofsymptomsoverhourstoafewweeks,oftenassociatedwithphysicaloremotionalstress,suggestsatriggerinitiatinganervoussysteminsultresultinginpermanentneurologicdisability. SIMILARITY:SwissProt:P13637##BelongstothecationtransportATPase(P-type)family.TypeIICsubfamily. |
MolecularWeight | broadbandatanapparentmolecularweightof48-55kDaduetoglycosylation |