UniProtSummary | FUNCTION:SwissProt:P11137#TheexactfunctionofMAP2isunknownbutMAPsmaystabilizethemicrotubulesagainstdepolymerization.Theyalsoseemtohaveastiffeningeffectonmicrotubules. SIZE:1,827aminoacids(Isofoim1;MAP2b);471aminoacids(Isofoim2;MAP2c);1,823aminoacids(Isofoim3;MAP2a);559aminoacids(Isofoim4;MAP2d); SUBCELLULARLOCATION:Cytoplasm.Cytoskeleton. PTM:PhosphorylatedatserineresiduesinK-X-G-SmotifsbyMAP/microtubuleaffinity-regulatingkinase(MARK1orMARK2),causingdetachmentfrommicrotubules,andtheirdisassembly.Isoform2/MAP2cisprobablyphosphorylatedbyPKAatSer-323,Ser-354andSer-386andbyFYNatTyr-67. |