Immunogen | PurifiedrecombinanthumanMARCKS;Epitopemappedtothecarboxyl-terminal. |
Clone | 2F12 |
Host | Mouse |
Specificity | MARCKS |
Isotype | IgG1 |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | TheproteinencodedbythisgeneisasubstrateforproteinkinaseC.Itislocalizedtotheplasmamembraneandisanactinfilamentcrosslinkingprotein.PhosphorylationbyproteinkinaseCorbindingtocalcium-calmodulininhibitsitsassociationwithactinandwiththeplasmamembrane,leADIngtoitspresenceinthecytoplasm.Theproteinisthoughttobeinvolvedincellmotility,phagocytosis,membranetraffickingandmitogenesis. |
GeneSymbol | - MARCKS
- 80K-L
- MACS
- PRKCSL
- FLJ14368
- phosphomyristin
- MRACKS
- PKCSL
- FLJ90045
|
PurificationMethod | Ascites |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P29966#MARCKSisthemostprominentcellularsubstrateforproteinkinaseC.Thisproteinbindscalmodulin,actin,andsynapsin.MARCKSisafilamentous(F)actincross-linkingprotein. SIZE:332aminoacids;31555Da PTM:PhosphorylationbyPKCdisplacesMARCKSfromthemembrane.ItalsoinhibitstheF-actincross-linkingactivity. SIMILARITY:SwissProt:P29966##BelongstotheMARCKSfamily. |
MolecularWeight | nonegiven |