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Millipore/05-1312 | Anti-Ubiquityl-Histone H2B Antibody, clone 56/05-1312/100 µg
  • Millipore/05-1312 | Anti-Ubiquityl-Histone H2B Antibody, clone 56/05-1312/100 µg

Millipore/05-1312 | Anti-Ubiquityl-Histone H2B Antibody, clone 56/05-1312/100 µg

價(jià)格: ￥4680.00 市場價(jià): 7800.00
貨號(hào): 05-1312
品牌: Millipore
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    • Description
      CatalogueNumber05-1312
      TradeName
      • Upstate
      DescriptionAnti-Ubiquityl-HistoneH2BAntibody,clone56
      AlternateNames
      • H2BUb
      • HistoneH2B(ubiquityl)
      • HIST1H2B
      • H2BUbK119
      • H2BK119Ub
      BackgroundInformationHistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.HistonemodificationsregulateDNAtranscription,repair,recombination,andreplication.Themostcommonlystudiedmodificationsareacetylation,phosphorylation,methylation,andubiquitination.Thesemodificationscanalterlocalchromatinarchitecture,orrecruittrans-actingfactorsthatrecognizespecifichistonemodifications(the"histonecode"hypothesis).AnumberofstudieshaveimplicatedubiquitinatedH2Binheterochromaticgenesilencingandinthecontrolofgeneexpressionofseveralyeastgenes.
      ProductInformation
      FormatPurified
      Control
      • HeLacelllysate.
      PresentationPurifiedfromascitesbyproteinGchromatography.Suppliedat1mg/mlin0.1MTris-Glycine(pH7.4)150mMNaCl,0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Formaximumrecoveryofproduct,centrifugethevialpriortoremovingthecap.
      Applications
      ApplicationAnti-Ubiquityl-HistoneH2BAntibody,clone56isaMouseMonoclonalAntibodyfordetectionofUbiquityl-HistoneH2BalsoknownasH2BUb,HistoneH2B(ubiquityl),HIST1H2B&hasbeenvalidatedinWB.
      KeyApplications
      • WesternBlotting
      • ChromatinImmunoprecipitation(ChIP)
      BIOLOGicalInformation
      ImmunogenImmunogenusedwasabranchedpeptidecorrespondingtotheubiquitinationsiteonhumanH2B.
      EpitopeUbiquitylLys120
      Cloneclone56
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityRecognizeshistoneH2BwhenitisubiquitinatedatLys120butnotH2Binitsunmodifiedstate,orubiquitinunconjugatedtoH2B.Mr~25kDa.
      IsotypeIgG2aκ
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteBasedonsequencehomology,broadspeciescross-reactivityisexpected.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH2Bfamily.TranscriptsfromthisgenelackpolyAtails;instead,theycontainapalindromicterminationelement.
      Modifications
      • Ubiquitylation
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.

      Hasbroadantibacterialactivity.Maycontributetotheformationofthefunctionalantimicrobialbarrierofthecolonicepithelium,andtothebactericidalactivityofamnioticfluid.

      Subunitstructure:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.

      Subcellularlocation:Nucleus.

      Post-translationalmodification:MonoubiquitinationofLys-120bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.
      MolecularWeight~25kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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