UniProtSummary | FUNCTION:SwissProt:Q13547#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes. SIZE:482aminoacids;55103Da SUBUNIT:Partofthecorehistonedeacetylase(HDAC)complexcomposedofHDAC1,HDAC2,RBBP4andRBBP7.ThecorecomplexassociateswithMTA2,MBD2,MBD3,MTA1L1,CHD3andCHD4toformthenucleosomeremodelingandhistonedeacetylation(NuRD)complex,orwithSIN3,SAP18andSAP30toformtheSIN3HDACcomplex.ComponentofaBHChistonedeacetylasecomplexthatcontainsHDAC1,HDAC2,HMG20B/BRAF35,AOF2/LSD1,RCOR1/CoRESTandPHF21A/BHC80.TheBHCcomplexmayalsocontainZMYM2,ZNF217,ZMYM3,GSE1andGTF2I.Associateswiththe9-1-1complex;interactswithHUS1.FoundinacomplexwithDNMT3AandHDAC7.InteractswithBCOR,BRMS1L,DAXX,DNMT1,EP300,HCFC1,PCAF,PHB2,MIER1,JMJD2A/JHDM3A,MINT,NRIP1,RERE,SETDB1,SUV39H1,TGIF,TGIF2,UHRF1andUHRF2.Interactswiththenon-histoneregionofH2AFY.InteractswithHDAC9.ComponentofamSin3AcorepressorcomplexthatcontainsSIN3A,SAP130,SUDS3/SAP45,ARID4B/SAP180,HDAC1andHDAC2.InteractswithBANP,CBFA2T3andJARID1B.InteractswithSAP30L. SUBCELLULARLOCATION:Nucleus. TISSUESPECIFICITY:Ubiquitous,withhigherlevelsinheart,pancreasandtestis,andlowerlevelsinkidneyandbrain. PTM:SumoylatedonLys-444andLys-476;whichpromotesenzymaticactivity.DesumoylatedbySENP1.&PhosphorylationonSer-421andSer-423promotesenzymaticactivityandinteractionswithNuRDandSIN3complexes. SIMILARITY:SwissProt:Q13547##Belongstothehistonedeacetylasefamily.Type1subfamily. |