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Millipore/04-958 | Anti-Beta Catenin Antibody, clone 7F7.2/04-958/100 µg
  • Millipore/04-958 | Anti-Beta Catenin Antibody, clone 7F7.2/04-958/100 µg

Millipore/04-958 | Anti-Beta Catenin Antibody, clone 7F7.2/04-958/100 µg

價(jià)格: ￥3444.00 市場(chǎng)價(jià): 5740.00
貨號(hào): 04-958
品牌: Millipore
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    • Description
      CatalogueNumber04-958
      Replaces04-1002
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-BetaCateninAntibody,clone7F7.2
      AlternateNames
      • BetaCatenin
      • Catenin(cadherin-associatedprotein),beta1
      BackgroundInformationCateninsareproteinsfoundincomplexeswithcadherincelladhesionmoleculesofanimalcells.Thefirsttwocateninsthatwereidentifiedbecameknownasα-cateninandβ-catenin.α-catenincanbindtoβ-cateninandcanalsobindactin.β-cateninbindsthecytoplasmicdomainofsomecadherins.Whenβ-cateninwassequenceditwasfoundtobeamemberofthearmADIllofamilyofproteins.Theseproteinshavemultiplecopiesoftheso-calledarmadillorepeatdomainwhichisspecializedforprotein-proteinbinding.Anincreaseinβ-cateninproductionhasbeennotedinthosepeoplewhohaveBasalCellCarcinomaandleadstotheincreaseinproliferationofrelatedtumors.Whenβ-cateninisnotassociatedwithcadherinsandα-catenin,itcaninteractwithotherproteinssuchasCateninBetaInteractingProtein1(ICAT)andadenomatosispolyposiscoli(APC).Recentevidencesuggeststhatβ-cateninplaysanimportantroleinvariousaspectsofliverBIOLOGyincludingliverdevelopment(bothembryonicandpostnatal),liverregenerationfollowingpartialhepatectomy,HGF-inducedhepatpomegaly,liverzonation,andpathogenesisoflivercancer.
      ProductInformation
      FormatPurified
      Control
      • HEK293celllysate,PC12celllysate,NIH/3T3celllysate
      PresentationPurifiedmousemonoclonalIgG1κinbuffercontaining0.1MTris-Glycine,pH7.4,150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationThisAnti-BetaCateninAntibody,clone7F7.2isvalidatedforuseinWB,ICforthedetectionofBetaCatenin.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      ApplicationNotesWesternBlotAnalysis:0.5-2μg/mLofthislotdetectedbetacatenininHEK293celllysate.
      BiologicalInformation
      ImmunogenFulllength,GST-taggedrecombinantbetacatenin.
      Clone7F7.2
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityThisantibodyrecognizesbetacatenin.
      IsotypeIgG1κ
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryBeta-cateninisanadherensjunctionprotein.Adherensjunctions(AJs;alsocalledthezonulaadherens)arecriticalfortheestablishmentandmaintenanceofepitheliallayers,suchasthoseliningorgansurfaces.AJsmediateadhesionbetweencells,communicateasignalthatneighboringcellsarepresent,andanchortheactinCytoskeleton.Inservingtheseroles,AJsregulatenormalcellgrowthandbehavior.Atseveralstagesofembryogenesis,woundhealing,andtumorcellmetastasis,cellsformandleaveepithelia.Thisprocess,whichinvolvesthedisruptionandreestablishmentofepithelialcell-cellcontacts,mayberegulatedbythedisassemblyandassemblyofAJs.AJsmayalsofunctioninthetransmissionofthe"contactinhibition"signal,whichinstructscellstostopdividingonceanepithelialsheetiscomplete.[suppliedbyOMIM]
      GeneSymbol
      • CTNNB
      • CTNNB1
      • FLJ25606
      • FLJ37923
      • DKFZp686D02253
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway.
      SUBUNIT:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.ThestABIlizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossIBLyalsoRUVBL1andDUPLIN.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1binding(Bysimilarity).InteractswiththePDZdomainofTAX1BP3;thisinteractioninhibitsthetranscriptionalactivityofCTNNB1(Bysimilarity).InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2andMUC1.InteractswithSLC30A9.InteractswithXIRP1(Bysimilarity).
      SUBCELLULARLOCATION:Cytoplasm.Nucleus.Cytoplasm,cytoskeleton.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2andMUC1promotesnucleartranslocation.
      TISSUESPECIFICITY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon.
      MolecularWeight92kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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