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Millipore/04-735 | Anti-monomethyl-Histone H4 (Lys20) Antibody, clone NL314, rabbit monoclonal/04-735/100 µl
  • Millipore/04-735 | Anti-monomethyl-Histone H4 (Lys20) Antibody, clone NL314, rabbit monoclonal/04-735/100 µl

Millipore/04-735 | Anti-monomethyl-Histone H4 (Lys20) Antibody, clone NL314, rabbit monoclonal/04-735/100 µl

價(jià)格: ￥4680.00 市場價(jià): 7800.00
貨號(hào): 04-735
品牌: Millipore
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    • Description
      CatalogueNumber04-735
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-monomethyl-HistoneH4(Lys20)Antibody,cloneNL314,rabbitmonoclonal
      AlternateNames
      • H4K20me1
      • HistoneH4(monomethylK20)
      • histone4
      • H4
      • histoneH4
      • histonecluster4
      • H4
      BackgroundInformationHistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.Thefourcorehistones,H2A,H2B,H3,andH4,assembleintoanoctamer(2moleculesofeach).Histonesaremodifiedpost-translationallybytheactionsofenzymesinboththenucleusandcytoplasm.Thesemodifications,whichincludeacetylation,phosphorylation,methylation,andubiquitin-ation,occurpredominantlyontheN-terminalandC-terminaltailsthatextendbeyondthenucleosomecoreparticle.TrimethylationofhistoneH4onlys20(H4-K20me3)selectivelymarksconstitutivepericentromerichetero-chromatinandimprintingcontrolregions,whilemono-anddimethylationarebroadlydistributedbutprincipallyenrichedineuchromatinregions.AlthoughtheBIOLOGicalfunctionofH4K20meremainspoorlyunderstood,studiessuggestthatH4-K20me2isinvolvedintheguidanceofDNArepairproteinstoDNAstrandbreaks,whereasH4K20me1isassociatedwithchromatincondensationprocesses.PR-Set7(alsoknownasSET8)specificallycatalyzesmonomethylationofH4K20me1.
      ProductInformation
      FormatCultureSupernatant
      Control
      • HeLaacidextracts
      PresentationCulturedsupernantantin0.05%sodiumazide
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      Formaximumrecoveryofproduct,centrifugethevialpriortoremovingthecap.
      Applications
      ApplicationUseAnti-monomethyl-HistoneH4(Lys20)Antibody,cloneNL314(rabbitmonoclonalantibody)validatedinWB,Mplextodetectmonomethyl-HistoneH4(Lys20)alsoknownasH4K20me1,HistoneH4(monomethylK20).
      KeyApplications
      • WesternBlotting
      • Multiplexing
      ApplicationNotesImmunoblotAnalysis:
      A1:4000dilutionofapreviouslotdetectedmethylatedhistoneH3inacidextractedproteinsfromHeLacells.TheantibodydidnotdetectunmethylatedrecombinantHistoneH3.

      Multiplexing:
      Beadlyte?Histone-PeptideSpecificityAssay:1:2,000-1:30,000dilutionsofapreviouslotwereincubatedwithhistoneH4peptidescontainingvariousmodificationsconjugatedtoLuminex?microspheres.Specificitytomonomethyl-histoneH4(Lys20)wasdemonstrated(FigureC).
      BiologicalInformation
      ImmunogenKLH-conjugated,syntheticpeptidecontainingthesequence…HR[mmK]V…,inwhichmmKcorrespondstomonomethyl-lysineatresidue20ofhumanhistoneH4.
      CloneNL314
      HostRabbit
      SpecificityRecognizesmonomethyl-histoneH4(Lys20),Mr~10kDa.
      IsotypeIgG
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteHuman.TheimmunizingsequenceisconservedfromTetrahymenatohuman,sobroadspeciescross-reactivityisexpected.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6.
      GeneSymbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      Modifications
      • Methylation
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      SIZE:103aminoacids;11367Da
      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      SUBCELLULARLOCATION:Nucleus.
      PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins.
      SIMILARITY:SwissProt:P62805##BelongstothehistoneH4family.
      MolecularWeight10kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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