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Millipore/04-1098 | Anti-phospho-Jak2 (Tyr1007/Tyr1008) Antibody, clone E132, rabbit monoclonal/04-1098/100 µL
  • Millipore/04-1098 | Anti-phospho-Jak2 (Tyr1007/Tyr1008) Antibody, clone E132, rabbit monoclonal/04-1098/100 µL

Millipore/04-1098 | Anti-phospho-Jak2 (Tyr1007/Tyr1008) Antibody, clone E132, rabbit monoclonal/04-1098/100 µL

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貨號(hào): 04-1098
品牌: Millipore
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    • Description
      CatalogueNumber04-1098
      DescriptionAnti-phospho-Jak2(Tyr1007/Tyr1008)Antibody,cloneE132,rabbitmonoclonal
      AlternateNames
      • Januskinase2
      • Januskinase2(aproteintyrosinekinase)
      • tyrosine-proteinkinaseJAK2
      BackgroundInformationJAK2(JanusKinase2)belongstotheemergingfamilyofnon-receptorJanustyrosinekinases,whichregulateaspectrumofcellularfunctionsdownstreamofactivatedcytokinereceptorsinthelympho-hematopoieticsystem.Immunologicalstimuli,suchasinterferonsandcytokines,inducerecruitmentofStattranscriptionfactorstocytokinereceptor-associatedJAK2.JAK2thenphosphorylatesproximalStatfactors,whichsubsequentlydimerize,translocatetothenucleusandbindtoCISelementsupstreamoftargetgenepromoterstoregulatetranscription.ThecanonicalJAK/Statpathwayisintegraltomaintaininganormalimmunesystembystimulatingproliferation,differentiation,survivalandhostresistancetopathogens.AlteringJAK/Statsignalingtoreducecytokineinducedpro-inflammatoryresponsesrepresentsanattractivetargetforanti-inflammatorytherapies.WithintheJAK2kinasedomain,thereisaregionthathasconsiderablesequencehomologytotheregulatoryregionoftheinsulinreceptor.
      ProductInformation
      FormatUnpurified
      Control
      • ImmunoprecipitationpelletsfromJurkatcelllysate+GM-CSF
      PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      • Immunocytochemistry
      • Immunoprecipitation
      ApplicationNotesImmunohistochemistryAnalysis:A1:50-100dilutionfromapreviouslotdetectedJak2inhumanlungadenocarcinomatissue.
      DotBlotAnalysis:DotBlotanalysisfromapreviouslotdetectedJak2onimmunogenphospho-peptideandnon-phosphopeptide.
      ImmunocytochemistryAnalysis:A1:50-100dilutionfromapreviouslotwasusedinIC.
      ImmunoprecipitationAnalysis:A1:50dilutionfromapreviouslotwasusedinIP.

      BIOLOGicalInformation
      ImmunogenPhospho-syntheticpeptidecorrespondingtoresiduessurroundingTyr1007andTyr1008ofhumanJak2.
      EpitopePhosphorylatedTyr1007/Tyr1008
      CloneE132
      HostRabbit
      SpecificityTheantibodyonlydetectsJak2phosphorylatedonTyr1007andTyr1008.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • EC2.7.10.2
      • JAK-2
      • JTK10
      • OTTHUMP00000021024
      • OTTHUMP00000043260
      Modifications
      • Phosphorylation
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:PlaysaroleinleptinsignalingandcontrolofbodyweightBysimilarity.Tyrosinekinaseofthenon-receptortype,involvedininterleukin-3andprobablyinterleukin-23signaltransduction.
      CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.
      SUBUNITSTRUCTURE:InteractswithSIRPAandSH2B1Bysimilarity.InteractswithIL23R,SKB1andSTAM2.
      SUBCELLULARLOCATION:Endomembranesystem;PeripheralmembraneproteinBysimilarity.Note:Whollyintracellular,possIBLymembraneassociatedBysimilarity.
      TISSUESPECIFICITY:Expressedinblood,bonemarrowandlymphnode.
      DOMAIN:Possessestwophosphotransferasedomains.ThesecondoneprobablycontainsthecatalyticdomainBysimilarity,whilethepresenceofslightdifferencessuggestadifferentrolefordomain1.
      PTM:Leptinpromotesphosphorylationontyrosineresidues,includingphosphorylationonTyr-813Bysimilarity.
      INVOLVEMENTINDISEASE:ChromosomalaberrationsinvolvingJAK2arefoundinbothchronicandacuteformsofeosinophilic,lymphoblasticandmyeloidleukemia.Translocationt(8;9)(p22;p24)withPCM1linkstheproteinkinasedomainofJAK2tothemajorportionofPCM1.Translocationt(9;12)(p24;p13)withETV6.DefectsinJAK2areacauseofsusceptibilitytoBudd-Chiarisyndrome[MIM:600880].Budd-Chiarisyndromeisaspectrumofdiseasestates,includinganatomicabnormalitiesandhypercoagulabledisorders,resultinginhepaticvenousoutflowocclusion.Clinicalmanifestationsobservedinthemajorityofpatientsincludehepatomegaly,rightupperquadrantpain,andaBDominalascites.
      DefectsinJAK2areassociatedwithpolycythemiavera(PV)[MIM:263300].PV,themostcommonformofprimarypolycythemia,iscausedbysomaticmutationinasinglehematopoieticstemcellleADIngtoclonalhematopoiesis.PVisamyeloproliferativedisordercharacterizedpredominantlybyerythroidhyperplasia,butalsobymyeloidleukocytosis,thrombocytosis,andsplenomegaly.FamilialcasesofPVareveryrareandusuallymanifestinelderlypatients.
      DefectsinJAK2genemaybeacauseofessentialthrombocythemia(ET)[MIM:187950].ETischaracterizedbyelevatedplateletlevelsduetosustainedproliferationofmegakaryocytes,andfrequentlyleadtothromboticandhaemorrhagiccomplications.
      DefectsinJAK2areassociatedwithfamilialmyelofibrosis[MIM:254450].Myelofibrosiswithmyeloidmetaplasiaisamyeloproliferativediseasewithannualincidenceof0.5-1.5casesper100,000individualsandageatdiagnosisaround60(anincreasedprevalenceisnotedinAshkenaziJews).Clinicalmanifestationsdependonthetypeofbloodcellaffectedandmayincludeanemia,pallor,splenomegaly,hypermetabolicstate,petechiae,ecchymosis,bleeding,lymphadenopathy,hepatomegaly,portalhypertension.
      DefectsinJAK2areacauseofacutemyelogenousleukemia(AML)[MIM:601626].AMLisamalignantdiseaseinwhichhematopoieticprecursorsarearrestedinanearlystageofdevelopment.
      SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.JAKsubfamily.
      Contains1FERMdomain.
      Contains1proteinkinasedomain.
      Contains1SH2domain.
      MolecularWeight~130kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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