Immunogen | Syntheticpeptidecorrespondingtoresiduesofhumanpro-Caspase-6. |
Clone | EP1325Y |
Host | Rabbit |
Specificity | Thisantibodyrecognizespro-Caspase6. |
Isotype | IgG |
SpeciesReactivity | |
SpeciesReactivityNote | Proventoreactinhuman. |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Thisproteinisprocessedbycaspases7,8and10,andisthoughttofunctionasadownstreamenzymeinthecaspaseactivationcascade.Alternativesplicingofthisgeneresultsintwotranscriptvariantsthatencodedifferentisoforms.[providedbyRefSeq].
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GeneSymbol | |
PurificationMethod | Unpurified |
UniProtNumber | |
UniProtSummary | FUNCTION:InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Cleavespoly(ADP-ribose)polymeraseinvitro,aswellaslamins.Overexpressionpromotesprogrammedcelldeath.
CATALYTICACTIVITY:StrictrequirementforAspatpositionP1andhasapreferredcleavagesequenceofVal-Glu-His-Asp-|-.
ENZYMEREGULATION:ActivationissuppressedbyphosphorylationatSer-257.Ref.5
SUBUNITSTRUCTURE:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya18kDa(p18)anda11kDa(p11)subunit.
SUBCELLULARLOCATION:Cytoplasm.
PTM:Cleavagesbycaspase-3,caspase-8or-10generatethetwoactivesubunits.
SEQUENCESIMILARITY:BelongstothepeptidaseC14Afamily.
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MolecularWeight | ~35kDa |